Recent progress in the design of G-quadruplex–based electrochemical aptasensors

Aptamer-based electrochemical sensors are now developed for the detection of a wide variety analytes including ions, low-molecular-weight molecules, proteins, and living cells. An aptamer-based sensor is an analytical device whose bio-sensing element (i.e. aptamer) immobilized on transducer surface. Aptasensors have attracted great attention because their high selectivity, sensitivity, stability; they could be miniaturized low production cost offer extraordinary flexibility in design assemblies. This review will emphasize recent developments aptasensors using aptamers that able to adopt particular G-quadruplex (G4) conformations, which secondary DNA structures formed from guanine-rich sequences. Indeed, G4 exhibits notable recognition properties inherent structuration.